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Tumor Targeting in Cancer Therapy Michel Page

Book Details:

Author: Michel Page
Published Date: 19 Nov 2010
Publisher: Humana Press Inc.
Language: English
Format: Paperback::463 pages
ISBN10: 161737251X
ISBN13: 9781617372513
File size: 47 Mb
Dimension: 178x 254x 24.38mm::879g

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The direct interaction between ferritin and tumors has been studied since the 1960s, when several research groups reported that human ferritin could be selectively taken up tumor cells [,,]; however, the targeting mechanism was unknown.In 1988, Fargion et al. Found that human ferritin was specifically bound to an unknown 100-kDa protein in several human cancer cell lines []. In addition, in tumor biology, many studies have also suggested that mitochondrial thiols are involved in tumorigenesis, tumor progression, metastasis of cancer cells, and tumor therapy resistance (122 – 124). Recent studies also suggested that H 2 O 2 could rely on thiol antioxidant systems to sense and transduce the redox signals. have been shown to promote tumor inﬁltration immune effector cells or to limit the recruitment of immunosuppres-sive cells to the tumor microenvironment.27,30 For example, this applies to doxorubicin and oxaliplatin, which kill cancer cells in a way that promotes the recruitment of DCs and CTLs coupled to the elicitation of tumor-targeting Cancer cells are hungry. To feed their rapid growth and division, their metabolism changes. Moreover, they use sugar (glucose) in a different way to normal cells. This animation, created Nature With the emergence of the tumor microenvironment as an essential ingredient of cancer malignancy, therapies targeting the host compartment of tumors have begun to be designed and applied in … We selected a unique antigen, FAPα, based on its preferential expression in cancer tissues (6, 7, 16, 27), and radiolabeled anti-FAPα antibodies have shown in vivo tumor targeting in cancer patients (17, 19). FAPα is distinctive in its cancer distribution, as it is not expressed the malignant epithelial cells but rather the Cancer therapy has developed around the concept of killing, or stopping the growth of, the cancer cells. Molecularly targeted therapy is the modern expression of this paradigm. Increasingly, however, the realization that the cancer has co-opted the normal cells of the stroma for its own survival has led to the concept that the tumor microenvironment (TME) could be targeted for effective The liposomes present great potential for applications in targeted delivery of chemotherapeutics in the treatment of cancer. The use of liposomal drug carriers as vehicles for targeting of chemotherapeutic agents to tumor tissues is based on their advantages over other dosage forms, represented their low systemic toxicity, their bioavailability, and their possibility to enhance the For example, targeted therapy may block the action of an abnormal protein (such as HER2) that stimulates the growth of breast cancer cells. For example, Trastuzumab (Herceptin�) or lapatinib (TYKERB�) may be given to a woman whose lab tests show that her breast tumor has too much HER2. Drug resistance, difficulty in specific targeting and self-renewal properties of cancer stem cells (CSCs) all contribute to cancer treatment failure and relapse. CSCs have been suggested as both the seeds of the primary cancer, and the roots of chemo- and radio-therapy resistance. The ability to precisely deliver drugs to target CSCs is an urgent need for cancer therapy, with nanotechnology Stroma-targeting therapy is alive and well and remains a promising strategy to overcome therapy resistance in PDA. The existence of CAF heterogeneity suggests that stroma subtyping might be useful to stratify patients to achieve the most therapeutic benefit from stroma-targeting therapy. Tumor-Targeting, MicroRNA-Silencing Porous Silicon Nanoparticles for Ovarian Cancer Therapy. Alessandro Bertucci. Alessandro Bertucci. Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, United States. Adoptive T-cell therapy of prostate cancer targeting the cancer stem cell antigen EpCAM Zhenling Deng, Yanhong Wu, Wenbo Ma, Shuren Zhang* and Yu-Qian Zhang* Abstract Background: Adoptive transfer of tumor infiltrating or circulating lymphocytes transduced with tumor antigen receptors has been examined in various clinical trials to treat human Thus it is evident that aerobic glycolysis in conjunction with the pentose shunt pathway provide multiple benefits to cancer cells such as promoting tumor progression and providing resistance to therapy. Hence, this key signature of cancer cells, tumor metabolism, particularly the tumor glycolysis, provides an ideal target for therapeutic Targeting the tumour stroma to improve cancer therapy S. R. Revisiting seed and soil: examining the primary tumor and cancer cell foraging in metastasis. D. E. Ecological therapy for Treatments targeting the androgen receptor, a mainstay of prostate cancer therapy, do not usually cure the disease and eventually lose their effectiveness. A major cause of this therapeutic resistance is the presence of neuroendocrine tumor cells, which are not sensitive to androgen inhibition. Li et al.determined that neuroendocrine prostate cancer cells express a chemokine receptor called Figure 2. Strategies used to target tumor microenvironment for cancer therapy. 2.1. Targeting the Extracellular Matrix The composition of the ECM is of great relevance to the prognosis of a given tumor [23]. The ECM is a three-dimensional structure of collagen, el … Tumor-targeting Dendrimers—a Nanotechnology based Cancer Therapy.Cancer remains as one of the leading causes of death worldwide, and millions of dollars are being invested into cancer research. Over the years, cancer treatment has expanded to include methods such as surgery, radiation therapy, chemotherapy, stem cell transplant, and most A new design strategy is also summarized, which is promising for future clinical targeting NPs/nanomedicines design. The targeting mechanism and design strategy will inspire new insights and thoughts on targeting design and will speed up precision medicine and contribute to … This animation covers the various effects of chemotherapy: cancer cell death, tumor death, destruction of normal cells and tissue. Also described are targeted cancer cell treatments, such as Thus they are emerging as novel targets for tumor metastasis therapy. In this review article, we describe how TAMs regulate tumor angiogenesis, invasion, metastasis, and then discuss the potential of applying TAMs-targeting treatment as a promising therapeutic strategy for metastatic cancer. The Radiation Oncology Targeting Cancer Campaign is an initiative of the Faculty of Radiation Oncology of the Royal Australian and New Zealand College of Radiologists (RANZCR)*. The Campaign aims to increase awareness of radiation therapy as an effective, safe and sophisticated treatment for cancer. STATE-OF-THE-ART REVIEW Targeting mutant p53 in cancer: a long road to precision therapy Fiamma Mantovani1,2, Dawid Walerych1,* and Giannino Del Sal1,2 1 …

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